Skrillex and ISOxo already have years of musical history, with a surprise B2B set at OMFG in 2022 and studio work even earlier. Recently, ISOxo earned six production credits on F*CK U SKRILLEX YOU THINK UR ANDY WARHOL BUT UR NOT!!, Skrillex’s GRAMMY-nominated mixtape-style album, and the pair reunited on stage at Niteharts in 2025, headlining the ISOKNOCK hometown festival. Their first official collaboration, Fuze, part of Skrillex’s hit me where it hurts x EP, followed shortly after and amassed over 5 million plays on Spotify.

ISOxo (left) and Skrillex (right) performing together in San Diego.

After years of anticipation, the duo suddenly dropped ‘Smoke,’ crediting vocals to UK-based drill rappers Cristale and TeeZandos. Out now on OWSLA, the massive second collab was widely previewed in individual shows and other artists’ performances. Knock2, Virtual Riot and RL Grime rinsed the energetic track, at the time known in the community as ‘Killers ID’. Even Afrojack played ‘Smoke’ at Ultra Music Festival, invigorating the crowd and continuing hype for the eventual release. Listen to ‘Smoke’ now:

The record wastes no time bringing in high-energy pounding bass and impeccably clean percussion. The drops, loaded with energy, create a perfectly chaotic atmosphere of intensity and drive audiences wild worldwide. In addition to Cristale’s and TeeZandos’ vocals, the track also includes several recognizable samples. One is from Skrillex’s own ‘Scatta’, and the other, “con los terroristas“, is a 2006 reggaeton cut, made world-famous after Baauer’s extremely viral ‘Harlem Shake.’ Notably, but perhaps unsurprisingly excluded, were the ‘Jungle Bae’ “hands up!” vocals often played in live versions, showcasing the track’s evolution before final release.

Coming up, Skrillex has a slew of festival appearances throughout the summer in Europe and North America. ISOxo has fewer shows announced, but confirmed appearances in New York City and at Factory Town, Miami. Conveniently, both artists will perform at Summer Smash, a hip-hop festival in Illinois, on Saturday, June 13. Both artists are full of surprises, so an unannounced reunion would not be out of the question.